Steps to reproduce:
1) Add Documents and Media Portlet in IE 8
2) Add a Document
3) In the Portlet, select the Configuration Wrench > Look and Feel. A popup box will open. Close the popup box
4) Select the Document via the Document checkbox and immediately uncheck it
5) Attempt to Drag the Document. Also, attempt to perform other actions in the Documents and Media Portlet.
This issue is fixed in 6.2.x however bisecting the issue is impossible due to this issue being fixed while the entire UI was being upgraded.